An impact of CMV and HHV-6 reactivation on the course of early period after hematopoietic stem cell transplantation in patients with hematologic malignancies

Objective. To assess the impact of CMV and HHV-6 reactivation on course early post-transplant period in patients with hematologic malignancies. Materials. Retrospective analysis medical records 339 malignancies who received hematopoietic stem cell transplantation (HSCT) was performed, markers infections were detected (specific IgG, EIA). Blood other materials from HSCT recipients tested (PCR) for viral DNA (up to Day 100). Results. Reactivation after discovered 177 (52,2 %): CMV-infection 23 %, 17,4 CMV+HHV-6 11,6 % recipients. predominantly identified blood, while more frequently GIT mucosa bone marrow. 40 99 had concomitant reactivation. In this group, clinical manifestation registered significantly frequently. Febrile neutropenia frequent reactivation, sepsis graft hypofunction diagnosed presence HHV-6+CMV infections. The direct correlation (using Spearman’s method) between terms leukopoiesis recovery, engraftment terms, transplant revealed. An herpetic late recovery confirmed using logistic regression; its chimerism 72 cases, failure occurred Conclusion. correlates contributes development complications, is an additional factor aggravating period.